Tracking the longitudinal course of physiologic and mental health functioning among individuals in substance use disorder treatment - Summary - MDSpire

Tracking the longitudinal course of physiologic and mental health functioning among individuals in substance use disorder treatment

  • By

  • Wendy Insalaco

  • Charlotte Clapham

  • Brett Gelino

  • Jami Mayo Barney

  • Brianna Billings

  • Jennifer D. Ellis

  • J. Gregory Hobelmann

  • Andrew S. Huhn

  • Vadim Zipunnikov

  • Jill A. Rabinowitz

  • June 10, 2026

  • 0 min

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Objective:

To examine the longitudinal associations of resting heart rate (RHR) and heart rate variability (HRV) with self-reported stress, anxiety, and depressive symptoms among individuals in substance use disorder (SUD) treatment.

Approach:
    Key Findings:
    • 39% of participants with decreased RHR reported decreased stress.
    • 42% of participants with decreased RHR reported decreased anxiety.
    • 39% of participants with decreased RHR reported improved depressive symptoms.
    • 39% of participants with increased HRV reported decreased stress.
    • 39% of participants with increased HRV reported improved anxiety.
    • 41% of participants with increased HRV reported reduced depressive symptoms.
    Interpretation:

    Changes in physiological and mental health metrics during the first month of treatment varied among participants, indicating the need for integrated monitoring.

    Limitations:
    • Small sample size (N = 59) may limit generalizability.
    • Short duration of monitoring (first month of treatment) may not capture long-term trends.
    Conclusion:

    The study highlights the importance of integrating physiological measures with self-reported mental health assessments to better understand changes during SUD treatment.

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