To systematically evaluate the rate and risk factors for unplanned readmission in patients with ischemic stroke (IS), providing an evidence-based foundation for developing targeted prevention strategies.
Key Findings:
A total of 44 studies involving 1,274,267 patients were included.
Pooled 30-day readmission rate was 14.2% (95% CI 11–18%).
Readmission rates were 13.9% at 90 days and 30.3% at 12 months.
Higher readmission rates observed in Asian settings (17.2%) compared to North America (11.7%).
Risk factors for 30-day readmission included atrial fibrillation (OR 1.34), heart failure (OR 1.59), diabetes (OR 1.29), and prior stroke (OR 1.50).
Infection (25.1%), recurrent stroke (21.8%), and cardiac events (13.7%) were common causes of readmission.
Interpretation:
The study clarifies the rate and key risk factors for unplanned readmission in IS patients, aiding in the identification of high-risk individuals and informing targeted interventions.
Limitations:
Substantial heterogeneity across studies (I2 > 90%), which may limit the applicability of the findings.
Variability in healthcare systems and study designs may affect generalizability.
Potential publication bias and exclusion of non-English studies.
Conclusion:
This meta-analysis provides updated insights into unplanned readmission rates and risk factors in ischemic stroke patients, supporting improved care transitions and targeted interventions.
