Objective:

To synthesize laboratory and clinical perspectives on the interaction between spinal cord injury and gut microbiota.

Approach:

Key Findings:

• Spinal cord injury disrupts intestinal function and triggers gut microbiota imbalance.
• Gut microbiota can produce metabolites that exacerbate neuroinflammation in the spinal cord.
• The relationship between gut microbiota dysbiosis and spinal cord injury is bidirectional.
• A significant reduction in butyrate-producing bacteria and increased pro-inflammatory cytokines have been observed post-SCI.

Interpretation:

This review highlights the complex interplay between gut microbiota and spinal cord injury.

Limitations:

• Standardized and effective clinical treatments for gut microbiota modulation in SCI remain elusive.
• Current research may not fully address the translational bottlenecks and safety risks associated with microbiota interventions.

Conclusion:

This study provides insights into the mechanisms linking spinal cord injury and gut microbiota.

Attribution Notice

This content is an AI-generated, fully rewritten summary based on a published scholarly article. It does not reproduce the original text and is not a substitute for the original publication. Readers are encouraged to consult the source for full context, data, and methodology.