Objective:

To determine the comparative effectiveness and safety of all available preventive treatments for vestibular migraine, including pharmacological and non-pharmacological options, using network meta-analysis.

Approach:

Key Findings:

• All medications significantly reduced vertigo attacks, indicating their effectiveness in managing vestibular migraine.
• Propranolol showed the largest benefits among traditional migraine preventives, suggesting its potential as a first-line treatment.
• CGRP antibody galcanezumab demonstrated the strongest evidence quality and best tolerability, highlighting its promise in clinical use.

Interpretation:

The analysis aids clinicians and patients in choosing treatments by balancing effectiveness, evidence quality, and side effects, highlighting the need for direct comparisons of promising treatments.

Limitations:

• Potential bias due to varying diagnostic criteria over time and in study selection.
• Limited number of head-to-head trials for comprehensive comparisons, affecting the robustness of conclusions.
• Risk of bias in included studies, particularly in observational studies.

Conclusion:

The findings underscore the importance of further direct comparison studies to enhance clinical guidance for vestibular migraine treatments, ultimately improving patient outcomes.

Source

Based on findings from:

Evaluating the Efficacy and Safety of Preventive Therapies for Vestibular Migraine: A Systematic Review and Network Meta-Analysis

Sindhu Vasireddy, Shankar Biswas, Raja Kollu, Elangovan Krishnan, Mohammed Semaal Khan, Fasil C, Arjun Jayakumar, Reena Acharya. Bmc Neurology, 2025.

https://link.springer.com/article/10.1186/s12883-025-04490-0

Attribution Notice

This content is an AI-generated, fully rewritten summary based on a published scholarly article. It does not reproduce the original text and is not a substitute for the original publication. Readers are encouraged to consult the source for full context, data, and methodology.