Objective:

To report a rare case of synchronous double primary tumors involving combined hepatocellular-cholangiocarcinoma and gallbladder adenocarcinoma, analyze clinical data, imaging findings, and treatment, and discuss its significance in the context of existing literature.

Key Findings:

• The patient had synchronous double primary tumors: cHCC-CCA and gallbladder adenocarcinoma.
• Imaging techniques (CT and MRI) were crucial for diagnosis, providing detailed insights into tumor characteristics.
• Postoperative recovery was successful with significant symptom improvement.

Interpretation:

This case highlights the rarity of synchronous double primary tumors in the liver and gallbladder, emphasizing the importance of advanced imaging and multidisciplinary approaches in diagnosis and treatment, which could inform future clinical practices.

Limitations:

• The rarity of the case limits generalizability and may introduce biases.
• Long-term follow-up data is not provided, which is essential for assessing outcomes.

Conclusion:

This is the first reported case of synchronous double primary cHCC-CCA and gallbladder adenocarcinoma, contributing to the understanding of multiple primary cancers and suggesting avenues for future research and clinical practice.