Objective:

To examine whether sugar-sweetened beverages (SSB) or artificially sweetened beverages (ASB) are associated with an increased incidence of liver cancer.

Approach:

Key Findings:

• An increase of 1 beverage/day in SSB intake was associated with a 10% increased risk of hepatocellular carcinoma (HCC) and a 15% increased risk of intrahepatic cholangiocarcinoma (ICC).
• No association was found between ASB consumption and liver cancer, HCC, or ICC in adjusted models.

Interpretation:

Remove unsupported conclusions and interpretations.

Limitations:

• Data on SSB and ASB consumption were primarily collected at a single time point, limiting the assessment of consumption pattern changes over time.
• Potential residual confounding or mediation by metabolic dysregulation was not fully addressed.
• The cohorts included span from 1984 to 2009, and changes in artificial sweeteners over time may affect risk assessment.
• Interactions with other liver cancer risk factors, such as viral hepatitis, were not explored.

Conclusion:

Remove recommendations and implications not directly stated in the source.

Sources:

• McGlynn et al Study
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