To evaluate the accuracy of the SCORE2 model in predicting cardiovascular events (CVE) risk in primary care settings, particularly among adult patients in the Netherlands.
Key Findings:
The mean observed 10-year CVE risk was 10.1%, significantly higher than the model-predicted risk of 6.2%, indicating a potential gap in treatment for at-risk patients.
O/E ratios were 1.54 for females and 1.68 for males, indicating underestimation by the SCORE2 model.
Approximately 35% of patients may have missed preventive treatments due to the model's underestimation.
Interpretation:
The SCORE2 model may not accurately reflect the CVE risk in primary care, necessitating recalibration to ensure that treatment decisions are based on accurate risk assessments.
Limitations:
The study is based on a specific population in the Netherlands, which may limit generalizability to other regions or populations.
The retrospective nature of the study may introduce biases in data interpretation, affecting the reliability of the findings.
Conclusion:
The SCORE2 model underestimates CVE risk in primary care, highlighting the need for improved calibration to ensure appropriate preventive treatment.
