A systematic review of AI for predicting glaucoma progression: challenges and recommendations towards clinical implementation - Summary - MDSpire

A systematic review of AI for predicting glaucoma progression: challenges and recommendations towards clinical implementation

  • By

  • Yichuan G. Liang

  • Leo Fan

  • Armando Teixeira-Pinto

  • Gerald Liew

  • Andrew J. R. White

  • January 22, 2026

  • 0 min

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Objective:

To survey the performance of AI models designed to predict glaucoma progression, emphasizing their clinical relevance and assessing predictive accuracy, strengths, and limitations for implementation.

Key Findings:
  • AI models show promise in predicting glaucoma progression, with some approaching diagnostic task performance, such as [specific model or study].
  • Significant heterogeneity and inconsistency exist in current AI approaches for glaucoma progression, highlighting the need for standardization.
  • Key issues include interpreting AI outputs, integrating AI into clinical pathways, and establishing consistent reporting guidelines, which are critical for effective implementation.
Interpretation:

AI has the potential to enhance glaucoma management through improved prediction of disease progression, but challenges in implementation and standardization must be addressed to realize this potential.

Limitations:
  • High variability in study designs and outcomes, which may affect the generalizability of findings.
  • Lack of clinically applicable tools for personalized treatment based on AI predictions, necessitating further research.
  • Insufficient exploration of AI model output interpretation and integration into clinical workflows, which could hinder practical application.
Conclusion:

The review highlights the urgent need for rigorous validation and regulatory assessment of AI tools for glaucoma progression prediction, alongside actionable recommendations for future clinical implementation.

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