To systematically review and analyze the diagnostic value of PET tracers for parathyroid localization in patients with primary hyperparathyroidism (pHPT), emphasizing their potential to improve surgical outcomes.
Key Findings:
99Tc-sestamibi SPECT-CT has a sensitivity of 63-84% for parathyroid localization, indicating a significant number of cases may remain undetected.
PET imaging, particularly with 11C-MET, shows promise for improved sensitivity in detecting pathological parathyroid glands, which could enhance surgical planning.
The performance of PET varies based on tracer characteristics and hospital-specific factors, highlighting the need for tailored approaches.
Interpretation:
PET imaging, especially with 11C-MET, may enhance the localization of parathyroid glands in pHPT, potentially improving surgical outcomes by allowing for more precise interventions.
Limitations:
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Conclusion:
PET tracers, particularly 11C-MET, represent a promising advancement in the imaging of parathyroid glands, warranting further investigation and standardization in clinical practice, especially in terms of tracer selection and imaging protocols.
by Wouter P. Kluijfhout, Jesse D. Pasternak, Frederick Thurston Drake, Toni Beninato, Jessica E. Gosnell, Wen T. Shen, Quan-Yang Duh, Isabel E. Allen, Menno R. Vriens, Bart de Keizer, Miguel H. Pampaloni, Insoo Suh
