Decreased TLR4 expression and NLRP3 inflammasome activation markers were observed.
Irisin upregulated miR-451a and miR-7-5p while downregulating miR-223-3p.
Inhibition of miR-451a diminished the anti-inflammatory effects of irisin.
Interpretation:
Irisin may exert anti-inflammatory effects in microglia through modulation of specific microRNAs and the TLR4/NLRP3 pathway, suggesting a potential therapeutic role in neuroinflammation associated with Alzheimer's disease.
Limitations:
The study was conducted in vitro, limiting the applicability of findings to in vivo conditions.
Further investigation is needed to confirm relevance in actual disease contexts.
Conclusion:
Irisin shows promise in modulating inflammatory responses in microglia, potentially offering insights into therapeutic strategies for Alzheimer's disease-related neuroinflammation.
by Roberta Mancuso, Marina Saresella, Riccardo Nuzzi, Simone Agostini, Ivana Marventano, Ambra Hernis, Francesca La Rosa, Federica Piancone, Mario Clerici
