Uncommon Case of Disseminated Talaromyces marneffei Infection Manifesting as Acute Pancreatitis in a Patient with HIV-1 - Summary - MDSpire

Uncommon Case of Disseminated Talaromyces marneffei Infection Manifesting as Acute Pancreatitis in a Patient with HIV-1

  • By

  • Yanqi Peng

  • Mi Zhang

  • Dandan Yang

  • Yuanlu Shu

  • Jincheng Lou

  • Hongli Fan

  • Zhenglun Li

  • Suyun Lei

  • Xingqi Dong

  • Li Gao

  • December 23, 2025

  • 0 min

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Objective:

To report a rare case of acute pancreatitis caused by Talaromyces marneffei in a patient with HIV-1/AIDS, highlighting its significance in clinical practice.

Key Findings:
  • The patient exhibited severe acute pancreatitis with elevated α-amylase and lipase levels.
  • Blood cultures revealed a large number of yeast-like fungal structures.
  • The patient had a history of irregular ART use, contributing to immunocompromised status.
  • Clinical progression and treatment response data should be added.
Interpretation:

This case highlights the potential for Talaromyces marneffei to cause acute pancreatitis in immunocompromised patients, emphasizing the need for awareness among clinicians and its implications for clinical practice.

Limitations:
  • The case is singular and may not represent broader trends.
  • Lack of imaging studies due to patient instability limited further assessment.
  • Potential biases in case reporting should be acknowledged.
Conclusion:

Talaromyces marneffei should be considered in differential diagnoses for acute pancreatitis in HIV-1/AIDS patients, particularly in endemic regions, emphasizing the rarity of this case and its implications for future research.

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