To provide a comprehensive overview of normal-SUA gout, covering its prevalence, pathogenic mechanisms, distinctive clinical features, diagnostic strategies, and current treatment approaches.
Approach:
Key Findings:
Normal serum uric acid levels can occur during acute gout flares, complicating diagnosis.
Normal-SUA gout often presents with more pronounced inflammation and may mimic infections.
Advanced imaging techniques like ultrasound and dual-energy CT enhance the diagnosis of normal-SUA gout.
Interpretation:
Normal-SUA gout is frequently under-recognized, leading to delayed diagnosis and inappropriate treatments.
Limitations:
Variability in reported prevalence of normal SUA during acute gout attacks across studies.
Lack of systematic evaluation of imaging techniques in diverse populations.
Conclusion:
Raising awareness of normal-SUA gout is essential for improving diagnostic accuracy and clinical outcomes.