Normal serum uric acid gout: a neglected and challenging condition - Summary - MDSpire

Normal serum uric acid gout: a neglected and challenging condition

  • By

  • Xiu Hong Yang

  • Xiao Li Zhan

  • Qing Xia Xuan

  • Hui Min Jin

  • Zhi Bin Ye

  • June 11, 2026

  • 0 min

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Objective:

To provide a comprehensive overview of normal-SUA gout, covering its prevalence, pathogenic mechanisms, distinctive clinical features, diagnostic strategies, and current treatment approaches.

Approach:
    Key Findings:
    • Normal serum uric acid levels can occur during acute gout flares, complicating diagnosis.
    • Normal-SUA gout often presents with more pronounced inflammation and may mimic infections.
    • Advanced imaging techniques like ultrasound and dual-energy CT enhance the diagnosis of normal-SUA gout.
    Interpretation:

    Normal-SUA gout is frequently under-recognized, leading to delayed diagnosis and inappropriate treatments.

    Limitations:
    • Variability in reported prevalence of normal SUA during acute gout attacks across studies.
    • Lack of systematic evaluation of imaging techniques in diverse populations.
    Conclusion:

    Raising awareness of normal-SUA gout is essential for improving diagnostic accuracy and clinical outcomes.

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