Objective:

To evaluate the effectiveness of a 5% nicotine pod-based electronic cigarette in achieving cigarette abstinence compared to a nicotine-free device.

Approach:

Key Findings:

• Participants in the 5% nicotine group had a higher rate of carbon monoxide-verified 7-day cigarette abstinence at 6 weeks (36.5%) compared to the nicotine-free group (11.5%).
• At 6 weeks, participants in the 5% nicotine group reported lower withdrawal and craving scores.
• No statistically significant differences were found in urinary NNAL levels between groups after adjustment for baseline measures.
• At the 10-week follow-up, self-reported abstinence was higher in the 5% nicotine group (32.7%) compared to the nicotine-free group (7.7%).

Interpretation:

Limitations:

• Small sample size and short follow-up duration.
• Single-site recruitment and limited racial and ethnic diversity.

Conclusion:

Participants assigned to a 5% nicotine electronic cigarette had higher rates of short-term cigarette abstinence compared to those assigned to a nicotine-free device, although the findings are limited by the study's design and population.

Sources:

• JAMA Network Open
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