Outcomes and Risk Factors for Influenza and Respiratory Syncytial Virus Lower Respiratory Tract Infections and Mortality in Patients With Lymphoma or Multiple Myeloma: A 7-Year Retrospective Cohort Study - Summary - MDSpire
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Outcomes and Risk Factors for Influenza and Respiratory Syncytial Virus Lower Respiratory Tract Infections and Mortality in Patients With Lymphoma or Multiple Myeloma: A 7-Year Retrospective Cohort Study
To investigate outcomes and risk factors of lower respiratory tract infections (LRI) and mortality secondary to respiratory syncytial virus (RSV) or influenza virus (IFV) infections in patients with lymphoma or multiple myeloma (MM), highlighting the significance of these infections in this vulnerable population.
Key Findings:
440 patients analyzed with 490 viral episodes: 297 (61%) with MM, 193 (39%) with lymphoma.
62% were diagnosed with URI and 38% with LRI at presentation, with specific percentages noted for clarity.
57% were hospitalized, 8% required ICU transfer, and 4% died within 30 days.
Risk factors for LRI included RSV infection, smoking, steroid exposure, lymphopenia, and high serum creatinine.
30-day mortality was associated with MM diagnosis, smoking, lymphopenia, and nosocomial infection.
Interpretation:
The study highlights a significant burden of IFV and RSV infections in lymphoma and MM patients, identifying key risk factors that could guide clinical management and improve patient outcomes.
Limitations:
Retrospective design may introduce biases affecting data accuracy.
Data limited to a single institution, potentially affecting generalizability.
No validated scoring index for predicting outcomes in this population.
Conclusion:
Identifying risk factors for LRI and mortality in lymphoma and MM patients with RSV or IFV infections can help in managing high-risk patients effectively, ultimately improving clinical outcomes.
by Tali Shafat, Daniel De-la-Rosa-Martinez, Fareed Khawaja, Ying Jiang, Amy Spallone, Marjorie Vieira Batista, Ella Ariza-Heredia, Diana Vilar-Compte, Sairah Ahmed, Melody Becnel, Roy F Chemaly
