Multicenter Validation of Clinical Sepsis Phenotypes - Summary - MDSpire

Multicenter Validation of Clinical Sepsis Phenotypes

  • By

  • Chang Ho Yoon

  • Daniel Sjöholm

  • Kristin E. Wickstrøm

  • Anders Skyrud Danielsen

  • Christian Prebensen

  • John Karlsson Valik

  • Aleksander Rygh Holten

  • Erik Koldberg Amundsen

  • A. Sarah Walker

  • David W. Eyre

  • Valeria Vitelli

  • Pontus Nauclér

  • June 1, 2026

  • 0 min

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Objective:

To validate the SENECA sepsis phenotypes in diverse healthcare settings outside the US, addressing the need for external validation.

Key Findings:
  • The study aimed to replicate the SENECA phenotypes in different populations.
  • Each site produced site-specific clinical phenotypes based on the same clustering methodology.
Interpretation:

Limitations:
  • Variability in epidemiologic factors and healthcare practices across sites.
  • Potential differences in data availability and patient characteristics.
Conclusion:

Original Source(s)

Multicenter Validation of Clinical Sepsis Phenotypes

  • by Chang Ho Yoon, Daniel Sjöholm, Kristin E. Wickstrøm, Anders Skyrud Danielsen, Christian Prebensen, John Karlsson Valik, Aleksander Rygh Holten, Erik Koldberg Amundsen, A. Sarah Walker, David W. Eyre, Valeria Vitelli, Pontus Nauclér

  • June 1, 2026

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