To evaluate the predictive value of TCM constitution types and multimodal clinical data for comorbidity risk in patients with psoriasis, and to explore the association between TCM constitution and systemic treatment effectiveness and adverse events.
Approach:
Follow-Up: Participants will be followed to monitor comorbidity progression, assess the effectiveness of systemic therapies, and record adverse events.
Key Findings:
Psoriasis is associated with multiple systemic comorbidities, including cardiovascular diseases and metabolic disorders.
Individual variability in treatment response to systemic therapies is significant among psoriasis patients.
TCM constitution theory may provide insights into the variability of treatment outcomes and comorbidity risk.
Interpretation:
The study aims to validate the relationship between TCM constitution types and psoriasis comorbidities and treatment responses.
Limitations:
The study relies on the accuracy of TCM constitution classification and multimodal data collection, and potential biases in participant selection and data interpretation may affect the validity of the outcomes.
Conclusion:
The study seeks to develop integrated predictive models for comorbidity risk and treatment outcomes in psoriasis, combining TCM-based features with modern clinical indicators.
Recognizing sustained switches between the two diseases can prevent premature discontinuation of effective biologics and point toward Janus kinase inhibitors, a 148-patient cohort suggests.
