Association between baseline-stratified trajectory subgroups of serum albumin and outcomes in critically ill patients with early sepsis-associated acute kidney injury: a retrospective study - Summary - MDSpire
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Association between baseline-stratified trajectory subgroups of serum albumin and outcomes in critically ill patients with early sepsis-associated acute kidney injury: a retrospective study
To explore the association between the serum albumin trajectory following early sepsis-associated acute kidney injury (SA-AKI) and the outcomes of sepsis patients in the intensive care unit (ICU).
Key Findings:
Five baseline-stratified trajectory subgroups of albumin levels were identified.
Patients with a steady-state trajectory at 2.0 g/dL had higher mortality risks at 30, 90, 180, and 365 days compared to those at 3.0 g/dL.
Patients with a trajectory at >4.1 g/dL also had higher 365-day mortality risk.
The association between serum albumin trajectories and mortality risk interacted with age and sex.
Interpretation:
Limitations:
The study is retrospective and relies on data from a single database.
Potential confounding factors may not have been fully accounted for.
