Objective:

To evaluate the changes in facial skin texture and fine wrinkles following delivery of self-crosslinking hyaluronic acid formulation through needle-free jet injection.

Approach:

• Study Design: A single-arm, non-randomized interventional study involving 30 women aged 40–55 years with Fitzpatrick skin types III–IV.
• Treatment Protocol: Participants underwent three treatment sessions at 4-week intervals using a self-crosslinking hyaluronic acid formulation delivered via needle-free jet injection.
• Outcome Measures: Outcomes included wrinkle and texture scores from 3D imaging, investigator-rated fine wrinkle severity, patient-reported improvement, and safety assessment.

Key Findings:

• At week 12, malar wrinkle and texture scores decreased by 8.7 and 7.2 points, respectively (p < 0.01).
• Pericommissural wrinkle and texture scores decreased by 7.5 and 4.9 points, respectively (p < 0.01).
• Investigator-rated fine wrinkle severity improved significantly from 7.28 ± 1.18 to 4.32 ± 1.36 (p < 0.01).
• 60% of participants reported moderate to marked improvement.
• Treatment-related reactions were mild and transient.

Interpretation:

The study reports improvements in imaging and investigator-rated outcomes following needle-free jet delivery of self-crosslinking HA for fine wrinkles and skin texture.

Limitations:

• The study was non-randomized and lacked a control group, which may affect the generalizability of the results.
• Long-term durability and comparative efficacy need further investigation.

Conclusion:

Further controlled studies with longer follow-up are needed to confirm the durability and comparative efficacy of this treatment.