Clinical Course of COVID-19 in Children With Adrenal Insufficiency: Results From National Data - Summary - MDSpire

Clinical Course of COVID-19 in Children With Adrenal Insufficiency: Results From National Data

  • By

  • Donatella Capalbo

  • Cristina Moracas

  • Laura Guazzarotti

  • Federico Baronio

  • Marianna Rita Stancampiano

  • Rita Ortolano

  • Mariella Valenzise

  • Carla Bizzarri

  • Giuseppa Patti

  • Silvia Longhi

  • Claudia Giavoli

  • Chiara Guzzetti

  • Silvia Zoletto

  • Crescenza Lattanzio

  • Paolo Cavarzere

  • Maria Elisabeth Street

  • Maria Felicia Faienza

  • Anna Grandone

  • Marco Cappa

  • Malgorzata Gabriela Wasniewska

  • Gianni Russo

  • Mohamad Maghnie

  • Mariacarolina Salerno

  • On behalf of the Study Group for Adrenal Diseases of the Italian Society for Pediatric Endocrinology and Diabetes

  • February 7, 2025

  • 0 min

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Objective:

To evaluate whether children with adrenal insufficiency (AI) are more susceptible to SARS-CoV-2 infection or at risk of severe COVID-19, focusing on specific outcomes such as infection rates and severity of illness.

Key Findings:
  • Prevalence of COVID-19 in the AI cohort was 12.9%, not increased compared to the general pediatric population.
  • Severity of COVID-19 was similar in AI subjects and controls, with specific percentages for asymptomatic, mild, and severe cases.
  • Only 5 patients (3.4%) experienced an adrenal crisis during severe COVID-19.
  • Hospitalization rates were the same in patients and controls (9.5%).
  • All subjects completely recovered with no COVID-related deaths.
Interpretation:

The study suggests that children with adrenal insufficiency do not have increased susceptibility to SARS-CoV-2 infection or higher risk for severe COVID-19.

Limitations:
  • Retrospective design may introduce bias, affecting the reliability of the findings.
  • Exclusion of patients with tertiary AI related to steroid use limits generalizability to the broader AI population.
  • Limited data on long-term outcomes post-COVID-19 restricts understanding of potential lasting effects.
Conclusion:

Findings indicate that AI in children does not correlate with increased risk of severe COVID-19, providing reassurance for this patient population and suggesting areas for future research.

Original Source(s)

Clinical Course of COVID-19 in Children With Adrenal Insufficiency: Results From National Data

  • by Donatella Capalbo, Cristina Moracas, Laura Guazzarotti, Federico Baronio, Marianna Rita Stancampiano, Rita Ortolano, Mariella Valenzise, Carla Bizzarri, Giuseppa Patti, Silvia Longhi, Claudia Giavoli, Chiara Guzzetti, Silvia Zoletto, Crescenza Lattanzio, Paolo Cavarzere, Maria Elisabeth Street, Maria Felicia Faienza, Anna Grandone, Marco Cappa, Malgorzata Gabriela Wasniewska, Gianni Russo, Mohamad Maghnie, Mariacarolina Salerno, On behalf of the Study Group for Adrenal Diseases of the Italian Society for Pediatric Endocrinology and Diabetes

  • February 7, 2025

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