Association between hypertension and risk of respiratory failure and mortality in patients with COVID-19: a retrospective cohort study with predictive model development - Summary - MDSpire
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Association between hypertension and risk of respiratory failure and mortality in patients with COVID-19: a retrospective cohort study with predictive model development
To investigate the association between hypertension and respiratory failure or mortality in patients with COVID-19 and develop predictive models for risk stratification.
Key Findings:
Hypertension was independently associated with increased risks of respiratory failure (OR = 2.196) and in-hospital mortality (OR = 2.945).
Eosinophil count and eGFR partially mediated the associations with respiratory failure (44.5% and 15.6%) and mortality (50.0% and 16.7%).
The predictive model for respiratory failure had an AUC of 0.788, while the model for mortality had an AUC of 0.694.
Interpretation:
Hypertensive COVID-19 patients face significantly higher risks of respiratory failure and mortality, with specific biomarkers mediating these risks, highlighting the importance of early risk identification.
Limitations:
Retrospective design may introduce bias.
Single-center study limits generalizability.
Potential confounding factors may not be fully accounted for.
Conclusion:
Hypertension significantly increases the risk of adverse outcomes in COVID-19 patients, and specific biomarkers can aid in risk stratification and clinical decision-making.
