HPV-associated moderately differentiated squamous cell carcinoma of the cervix with pathologically confirmed bladder invasion and radiologically presumed adrenal metastasis in a patient with prior lung adenocarcinoma resection: a rare case report and clinical discussion - Summary - MDSpire
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HPV-associated moderately differentiated squamous cell carcinoma of the cervix with pathologically confirmed bladder invasion and radiologically presumed adrenal metastasis in a patient with prior lung adenocarcinoma resection: a rare case report and clinical discussion
To report a rare case of cervical squamous cell carcinoma (CSCC) presenting with obstructive uropathy due to bladder invasion and suspected adrenal metastasis.
Approach:
Case Presentation: A 74-year-old woman with a history of lung adenocarcinoma presented with urinary symptoms and was diagnosed with HPV-associated CSCC after multiple investigations.
Diagnostic Procedures: Initial workup included bilateral ureteral stenting and transurethral bladder biopsy, followed by laparoscopic exploration and imaging studies.
Key Findings:
Bladder invasion by CSCC is rare and can mimic primary urologic disease.
The patient had a confirmed diagnosis of moderately differentiated CSCC with bladder wall invasion and suspected adrenal metastasis.
Immunohistochemistry showed a CK7+/CK20−/P63+/p16+ profile, aiding in diagnosis.
Interpretation:
CSCC can present with urinary symptoms due to bladder invasion.
Limitations:
The adrenal metastasis was not histologically confirmed.
The initial diagnosis was complicated by the patient's prior lung cancer history.
Conclusion:
CSCC presenting with obstructive uropathy is rare and often misdiagnosed; prompt gynecologic evaluation is crucial.
