Systemic immune-inflammation Index and blood pressure control are independent and interactive predictors of atrial fibrillation recurrence after ablation - Summary - MDSpire
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Systemic immune-inflammation Index and blood pressure control are independent and interactive predictors of atrial fibrillation recurrence after ablation
To assess the predictive value of pre-ablation SII for AF recurrence and explore the modifying effect of blood pressure (BP) control status in hypertensive patients.
Key Findings:
17.3% of patients experienced AF recurrence during a mean 34-month follow-up.
Elevated SII was independently associated with recurrence risk (HR per 100-unit increase: 1.138; P < 0.001).
Patients with both high SII and poorly controlled BP had a > 4-fold increased risk of recurrence (HR: 4.061).
SII outperformed conventional markers and improved model discrimination (C-statistic: 0.755).
Interpretation:
Pre-ablation SII is a superior predictor of AF recurrence after RFCA in hypertensive patients, particularly with poorly controlled BP, suggesting its utility in individualized risk stratification.
Limitations:
Retrospective design may introduce selection bias.
Single-center study limits generalizability of findings.
Potential confounding factors not fully accounted for.
Conclusion:
Combined assessment of SII and BP control may enhance individualized risk stratification for AF recurrence post-ablation.
