Case Report: Stevens–Johnson syndrome/toxic epidermal necrolysis overlap with ocular and urogenital involvement in an extremely preterm infant following broad-spectrum antibiotic exposure - Summary - MDSpire

Case Report: Stevens–Johnson syndrome/toxic epidermal necrolysis overlap with ocular and urogenital involvement in an extremely preterm infant following broad-spectrum antibiotic exposure

  • By

  • Adnan Hadid

  • Lana A. Shaiba

  • Mona Alkallabi

  • Khalid Nabil Nagshabandi

  • Nora Al-Saud

  • Rodhan Khaled Alnahdi

  • Layan Alsanad

  • Maee Barakeh

  • Naif Ahmed Alshehri

  • Khalid Faisal Alkahtani

  • Adel Abdulaziz Alsuhaibani

  • Abdulmalik Abdulaziz Alharbi

  • June 22, 2026

  • 0 min

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Objective:

To report a case of Stevens–Johnson syndrome/toxic epidermal necrolysis (SJS/TEN) overlap in an extremely preterm infant.

Approach:
    Key Findings:
    • The infant exhibited progressive mucocutaneous erosions and flaccid bullae, with epidermal detachment estimated at 25–30% body surface area, beginning at a corrected gestational age of 35 + 3 weeks.
    • Skin biopsy confirmed full-thickness keratinocyte necrosis with sub-epidermal blistering.
    • The infant later died from septic shock and multi-organ failure related to extreme prematurity and recurrent necrotizing enterocolitis.
    Interpretation:

    This case illustrates the diagnostic complexity of SJS/TEN in extremely premature infants.

    Limitations:
    • The rarity of SJS/TEN in neonates limits the generalizability of findings.
    • Existing literature lacks structured frameworks for diagnosis and treatment in extremely premature infants.
    Conclusion:

    The case highlights the importance of early suspicion and multidisciplinary supportive care in managing SJS/TEN overlap in vulnerable neonates.

Original Source(s)

Case Report: Stevens–Johnson syndrome/toxic epidermal necrolysis overlap with ocular and urogenital involvement in an extremely preterm infant following broad-spectrum antibiotic exposure

  • by Adnan Hadid, Lana A. Shaiba, Mona Alkallabi, Khalid Nabil Nagshabandi, Nora Al-Saud, Rodhan Khaled Alnahdi, Layan Alsanad, Maee Barakeh, Naif Ahmed Alshehri, Khalid Faisal Alkahtani, Adel Abdulaziz Alsuhaibani, Abdulmalik Abdulaziz Alharbi

  • June 22, 2026

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