The characteristics and clinical outcomes of atrial fibrillation patient in middle income country of Indonesia - Summary - MDSpire

The characteristics and clinical outcomes of atrial fibrillation patient in middle income country of Indonesia

  • By

  • Yoga Yuniadi

  • Putra S. Antara

  • Muzakkir Amir

  • Dicky A. Hanafy

  • Sunu B. Raharjo

  • Dony Y. Hermanto

  • M. Yamin

  • Hauda El-Rasyid

  • Benny Setiadi

  • Erika Maharani

  • Agus Harsoyo

  • Anggia C. Lubis

  • Pipin Ardhianto

  • Aruman Y. A. Binarso

  • Ardian Rizal

  • Rerdin Julario

  • Agung F. Chandranegara

  • Yoga Waranugraha

  • Chaerul Ahmad

  • Mohammad Iqbal

  • Ridwan Rasyid

  • Antonia A. Lukito

  • Haryadi Haryadi

  • Margono G. Suwandi

  • Alexander E. Tondas

  • Indah A. Putri

  • Beny Hartono

  • July 1, 2026

  • 0 min

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Objective:

To evaluate the clinical outcomes of Indonesian AF patients receiving warfarin-based treatment.

Approach:
  • Study Design: The OPTIMA study is a multicenter, prospective cohort study involving 1,599 AF patients across 25 centers in Indonesia.
  • Data Collection: Clinical characteristics, INR levels, and time in therapeutic range (TTR) were analyzed.
  • Endpoints: Primary endpoints included stroke/systemic embolism (efficacy) and major bleeding (safety).
  • Statistical Analysis: Cox proportional hazards regression and Kaplan–Meier analysis were used to assess outcomes.
Key Findings:
  • Mean CHA2DS2-VASc score was 2.43.
  • Mean time in therapeutic range (TTR) was only 30.1%.
  • Incidence rates per 100 patient-years were 1.32 for stroke, 1.51 for major bleeding, and 3.15 for mortality.
  • Stroke risk was highest in persistent/permanent AF, particularly affecting younger, working-age individuals.
Interpretation:

Warfarin management at the standard INR target of 2.0–3.0 was associated with poor anticoagulation quality.

Limitations:
  • The study's findings require confirmation in prospective trials.
  • Socioeconomic factors may influence the burden of AF-related strokes.
Conclusion:

Patients with average INR values of 1.6–2.5 experienced lower rates of stroke and major bleeding.

Original Source(s)

The characteristics and clinical outcomes of atrial fibrillation patient in middle income country of Indonesia

  • by Yoga Yuniadi, Putra S. Antara, Muzakkir Amir, Dicky A. Hanafy, Sunu B. Raharjo, Dony Y. Hermanto, M. Yamin, Hauda El-Rasyid, Benny Setiadi, Erika Maharani, Agus Harsoyo, Anggia C. Lubis, Pipin Ardhianto, Aruman Y. A. Binarso, Ardian Rizal, Rerdin Julario, Agung F. Chandranegara, Yoga Waranugraha, Chaerul Ahmad, Mohammad Iqbal, Ridwan Rasyid, Antonia A. Lukito, Haryadi Haryadi, Margono G. Suwandi, Alexander E. Tondas, Indah A. Putri, Beny Hartono

  • July 1, 2026

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