To evaluate long-term outcomes of antibiotic therapy versus appendectomy for uncomplicated acute appendicitis.
Key Findings:
38% of patients treated with antibiotics experienced a confirmed recurrence of appendicitis.
44% of patients initially treated with antibiotics ultimately underwent appendectomy during the follow-up.
More than half of patients treated with antibiotics avoided surgery over 10 years.
Cumulative complication rate was lower in the antibiotic group compared to the appendectomy group.
Quality of life and patient satisfaction were similar between both treatment groups.
Interpretation:
Antibiotic therapy remains a viable long-term option for selected patients with uncomplicated acute appendicitis, with a significant proportion avoiding surgery and experiencing low complication rates.
Limitations:
Study focused on carefully selected patients, limiting generalizability.
Potential for delayed diagnosis of appendiceal tumors in nonoperative management.
Conclusion:
Long-term results support the use of antibiotics as a treatment option for uncomplicated acute appendicitis, emphasizing shared decision-making between physicians and patients.
