Colorectal neoplastic emergencies in immunocompromised patients: preliminary result from the Web-based International Register of Emergency Surgery and Trauma (WIRES-T trial) - Summary - MDSpire

Colorectal neoplastic emergencies in immunocompromised patients: preliminary result from the Web-based International Register of Emergency Surgery and Trauma (WIRES-T trial)

  • By

  • Federico Coccolini

  • Alessio Mazzoni

  • Camilla Cremonini

  • Luigi Cobuccio

  • Marsia Pucciarelli

  • Guglielmo Vetere

  • Beatrice Borelli

  • Silvia Strambi

  • Serena Musetti

  • Mario Miccoli

  • Chiara Cremolini

  • Dario Tartaglia

  • Massimo Chiarugi

  • May 9, 2023

  • 0 min

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Objective:

To report preliminary data on colorectal neoplastic emergencies (CRNE) in immunocompromised patients from the WIRES-T trial, highlighting the clinical significance of these findings.

Key Findings:
  • 839 patients were analyzed, with 753 (80.7%) in the mild–moderate group and 86 (10.3%) in the severe group, indicating a predominance of mild cases.
  • Median age was 71.9 years for mild–moderate and 73 years for severe groups, suggesting age-related risks.
  • Mortality rates were 5.1% in mild–moderate and 12.8% in severe groups, highlighting the increased risk in severe cases.
  • The sigmoid colon was the most common site for CRNE, with 40% in mild–moderate and 32.6% in severe IC, indicating a need for targeted interventions.
  • ASA score was the only factor influencing mortality in both groups, underscoring its importance in clinical assessments.
Interpretation:

Immunocompromised patients with CRNE face significant risks and complications, with age and ASA score being critical factors in outcomes, necessitating tailored management strategies.

Limitations:
  • The study is preliminary and may not represent all cases of CRNE in immunocompromised patients, which could limit the applicability of the findings.
  • Data may be influenced by the multicenter nature and varying practices across institutions, potentially affecting consistency.
Conclusion:

CRNE in immunocompromised patients is a critical area requiring further investigation to improve outcomes and management strategies, particularly in understanding the role of ASA scores and age.

Original Source(s)

Colorectal neoplastic emergencies in immunocompromised patients: preliminary result from the Web-based International Register of Emergency Surgery and Trauma (WIRES-T trial)

  • by Federico Coccolini, Alessio Mazzoni, Camilla Cremonini, Luigi Cobuccio, Marsia Pucciarelli, Guglielmo Vetere, Beatrice Borelli, Silvia Strambi, Serena Musetti, Mario Miccoli, Chiara Cremolini, Dario Tartaglia, Massimo Chiarugi

  • May 9, 2023

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