Objective:

To assess the cumulative burden of high disease activity and its association with damage accrual and clinical outcomes in patients with childhood-onset systemic lupus erythematosus (cSLE).

Approach:

Key Findings:

• Includespecificstatisticalvaluesforclarity.

Interpretation:

Higher time-adjusted cHDAS is associated with increased risk of damage accrual in cSLE.

Limitations:

• Adddetailonhowlimitationsaffectfindings.

Conclusion:

Greater cumulative exposure to high disease activity is associated with damage in cSLE.

Source

Based on findings from:

Impact of high disease activity on damage accrual and disease outcomes in childhood-onset systemic lupus erythematosus

Ninlapat Jidmahawong, Butsabong Lerkvaleekul, Kwanchai Pirojsakul, Soamarat Vilaiyuk. Frontiers In Pediatrics, 2026.

https://www.frontiersin.org/journals/pediatrics/articles/10.3389/fped.2026.1765082/full

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This content is an AI-generated, fully rewritten summary based on a published scholarly article. It does not reproduce the original text and is not a substitute for the original publication. Readers are encouraged to consult the source for full context, data, and methodology.