Objective:

To evaluate the efficacy, safety, and predictive factors of transcatheter PFO closure for migraine in Chinese patients.

Approach:

Key Findings:

• Overall migraine responder rate was 83.98%, with 59.90% achieving complete/near-complete relief.
• Younger age (15–24 years) was associated with better outcomes (89.67% responder rate).
• More recent procedure year independently predicted higher success (OR = 0.89 per half-year delay).
• Procedure had a 100% technical success rate, with 3.49% minor complications and no major adverse events.
• Sustained therapeutic benefit observed after DAPT discontinuation (81.93% responder rate at >12 months).

Interpretation:

Transcatheter PFO closure is effective and safe for Chinese migraine patients, with sustained effects post-DAPT.

Limitations:

• Single-center study may limit generalizability.
• Retrospective design may introduce selection bias.

Conclusion:

Transcatheter PFO closure shows high efficacy and safety in treating migraines associated with PFO in a Chinese population.

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