Objective:

To evaluate the clinical efficacy and safety of ultrasound (US)-guided intra-articular injection with low-molecular-weight peptides (LWPs) derived from hydrolyzed collagen in patients with symptomatic CMC-1 OA.

Approach:

• Study Design: Prospective single-arm interventional study enrolling patients with symptomatic and radiographically confirmed CMC-1 OA.
• Intervention: US-guided intra-articular injection with LWPs.
• Endpoints: Primary endpoint: change in pain during activity after 3 months. Secondary outcomes include pain at rest, hand disability, grip and key pinch strength, rescue analgesic consumption, patient-reported improvement, ultrasonographic findings, treatment-related adv…

Key Findings:

• The study aims to assess whether the investigational treatment is associated with reduction in pain, improvement in hand function, and an acceptable safety profile over a follow-up period of up to 6 months.
• A secondary exploratory aim is to identify baseline clinical and US patterns potentially associated with clinical and imaging response.

Interpretation:

Conclusion:

The study is designed to provide insights into the efficacy and safety of LWPs in treating CMC-1 OA.