To investigate the association between in-hospital lowest serum albumin levels and clinical outcomes in ICU patients with spontaneous intracerebral hemorrhage (ICH).
Approach:
Study Design: Retrospective cohort study using pooled data from the Tianjin cohort and MIMIC-IV database.
Participants: Adult ICU patients with spontaneous ICH were included.
Primary Outcome: 28-day all-cause mortality.
Statistical Analysis: Multivariable Cox proportional hazards models and restricted cubic splines (RCS) were used to assess associations.
Key Findings:
28-day mortality increased from 17.2% in the >35 g/L group to 39.3% in the <30 g/L group (P < 0.001).
90-day mortality increased from 21.2% to 52.0% (P < 0.001).
Lower albumin levels were associated with significantly longer ICU and hospital stays (P < 0.001).
Subgroup analyses indicated that lower albumin levels were associated with increased mortality among patients without mechanical ventilation.
Interpretation:
Lower nadir serum albumin levels during hospitalization are associated with increased mortality in ICU patients with spontaneous ICH, with variations based on mechanical ventilation status.
Limitations:
Retrospective design may introduce bias.
Data sourced from two specific cohorts may limit generalizability.
Conclusion:
Nadir serum albumin level may serve as a prognostic marker for risk stratification in ICU patients with spontaneous ICH.
