To investigate the associations of psychosocial factors and fatigue with self-rated physical function in two demographically distinct cohorts of patients with systemic lupus erythematosus (SLE).
Approach:
Study Population: Cross-sectional study involving two distinct cohorts from Georgia (APPEAL) and California (CLUES) with confirmed SLE diagnoses.
Assessment Tools: Used PROMIS Physical Function Short Forms for physical function, SLAQ for fatigue, and PROMIS depression scale for depression assessment.
Key Findings:
Physical function is a core outcome in SLE and is significantly impacted by psychosocial factors such as fatigue, depression, perceived stress, coping, and self-efficacy.
Interpretation:
The findings suggest that psychosocial factors are robustly associated with physical function in SLE, independent of demographics and disease-related factors.
Limitations:
The study is cross-sectional, limiting causal inferences.
Findings may not be generalizable beyond the studied cohorts.
Conclusion:
Understanding the interplay between psychosocial factors and physical function can inform more equitable and patient-centered approaches to SLE management.
by Mrinalini Dey, Jessica Fitzpatrick, Maria Dall'Era, Charmayne Dunlop-Thomas, Courtney Hoge, S. Sam Lim, Patricia P. Katz, Jinoos Yazdany, Laura C. Plantinga
