Objective:

To analyze the clinical outcomes of endoscopic papillectomy (EP) and evaluate the feasibility and safety of a sequential radiofrequency ablation (RFA)-first strategy for complex ampullary tumors.

Approach:

Key Findings:

• Technical success rate was 100% with an overall short-term clinical success rate of 96.6%.
• Adverse events occurred in 20.5% of patients, with tumor size as a significant risk factor for complications.
• The short-term clinical success rate for the RFA group was 91.7%, with adverse events in 16.7% of patients.
• No significant difference in adverse events between RFA and non-RFA groups (p = 0.719).

Interpretation:

Further evaluation of long-term efficacy and complication rates is necessary.

Limitations:

• Retrospective study design may introduce bias.
• Short follow-up period limits assessment of long-term outcomes.

Conclusion:

The sequential application of EP and RFA may be a safe and effective strategy for managing selected cases of ampullary tumors.

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