Giant chronic splenic infarction mimicking splenic neoplasm in a patient with rheumatic heart disease: a case report - Summary - MDSpire

Large chronic splenic infarction resembling splenic tumor in a patient with rheumatic heart disease: a case study

  • By

  • Wei Tian

  • Xu Deng

  • Chunyuan Yang

  • Jianxing Tian

  • Zonglong Zhu

  • Rui Huang

  • Wei Pan

  • July 21, 2026

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Objective:

To highlight the atypical clinical features and diagnostic considerations of giant chronic splenic infarction, which can mimic splenic neoplasm in a patient with rheumatic heart disease.

Approach:
  • Case Presentation: A 73-year-old female with a history of rheumatic heart disease presented with recurrent epigastric pain for 2 years. Imaging suggested a splenic neoplasm, leading to splenectomy, which confirmed extensive splenic infarction. The patient had an uneventful postoperative recovery and was discharged on postoperative day 10.
Key Findings:
  • The patient had a large splenic mass with imaging features suggestive of a neoplasm.
  • Pathological examination revealed extensive splenic infarction with focal fibrosis and calcification.
  • Rheumatic heart disease may have contributed to splenic infarction as a cardioembolic source.
Interpretation:

Giant chronic splenic infarction can be misdiagnosed due to atypical clinical manifestations and imaging features that resemble tumors.

Limitations:
  • The exact etiology of the splenic infarction could not be definitively established.
  • No direct evidence of intracardiac thrombus or embolic material was identified.
  • The potential role of rheumatic heart disease as a contributing factor remains speculative.
Conclusion:

A comprehensive assessment of clinical history, laboratory results, imaging findings, and cardiac status is crucial to reduce misdiagnosis.

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