To investigate long-term mortality, complications, and quality of life among donors of living donor liver transplantation (LDLT), emphasizing the importance of donor safety.
Key Findings:
A total of 17 studies met eligibility criteria, with sample sizes ranging from 42 to 12,371 participants and variable follow-up periods from 1 to 11.5 years.
Biliary complications, including leakage and strictures, were the most frequently reported issues.
The incidence of bile leakage among donors ranged from 5 to 15%, while biliary strictures occurred in up to 1.7% of cases during follow-up.
Interpretation:
Long-term outcomes for living liver donors show a range of complications, particularly biliary issues, but the overall safety and quality of life remain critical for promoting living donation and warrant further investigation.
Limitations:
Small sample sizes and high loss to follow-up in many studies, which may impact the validity of the findings.
Variability in follow-up periods and outcomes reported across studies.
Conclusion:
Further research is needed to better understand the long-term implications of living liver donation, particularly in areas such as psychological impacts and donor safety.
