Hematopoietic stem cell transplantation disrupts age-related gut microbiota signatures in pediatric and adult recipients - Summary - MDSpire

Hematopoietic stem cell transplantation disrupts age-related gut microbiota signatures in pediatric and adult recipients

  • By

  • Davide Leardini

  • Marcello Roberto

  • Sara Roggiani

  • Edoardo Muratore

  • Marco Fabbrini

  • Gianluca Storci

  • Enrica Tomassini

  • Elisa Dan

  • Angela Schipani

  • Serena De Matteis

  • Barbara Sinigaglia

  • Daria Messelodi

  • Nicola Salvatore Bertuccio

  • Arcangelo Prete

  • Patrizia Brigidi

  • Francesca Bonifazi

  • Riccardo Masetti

  • September 25, 2025

  • 0 min

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Objective:

To analyze the gut microbiome (GM) changes in pediatric and adult patients undergoing allogeneic hematopoietic stem cell transplantation (allo-HSCT) and assess the influence of age on these changes, specifically focusing on children and adults.

Key Findings:
  • Higher alpha diversity pre-transplant is linked to better overall survival and lower GvHD-related mortality in adults.
  • Specific GM signatures correlate with increased risk of GvHD, including overgrowth of Enterococcus and loss of Blautia.
  • Pediatric studies show variable associations between post-allo-HSCT GM modifications and clinical outcomes, with distinct findings compared to adults.
Interpretation:

Age-related differences in GM composition may influence post-HSCT microbial dynamics, with pediatric patients experiencing greater microbiome disruption due to different transplant procedures, necessitating tailored interventions.

Limitations:
  • Pediatric studies have smaller sample sizes and greater variability compared to adult studies.
  • Differences in transplant procedures and clinical outcomes complicate direct comparisons between age groups.
  • Potential biases in sample collection or analysis methods may affect results.
Conclusion:

Understanding the impact of age on GM changes post-HSCT is crucial for optimizing patient outcomes and tailoring interventions for both pediatric and adult patients.

Original Source(s)

Hematopoietic stem cell transplantation disrupts age-related gut microbiota signatures in pediatric and adult recipients

  • by Davide Leardini, Marcello Roberto, Sara Roggiani, Edoardo Muratore, Marco Fabbrini, Gianluca Storci, Enrica Tomassini, Elisa Dan, Angela Schipani, Serena De Matteis, Barbara Sinigaglia, Daria Messelodi, Nicola Salvatore Bertuccio, Arcangelo Prete, Patrizia Brigidi, Francesca Bonifazi, Riccardo Masetti

  • September 25, 2025

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