Timing Considerations for Endovascular Intervention in Patients with Symptomatic Intracranial Atherosclerotic Stenosis: Insights from a Single-Center Real-World Analysis - Summary - MDSpire

Timing Considerations for Endovascular Intervention in Patients with Symptomatic Intracranial Atherosclerotic Stenosis: Insights from a Single-Center Real-World Analysis

  • By

  • Yang Yang

  • Xiaoya Wang

  • Jialiang Lu

  • Ye Li

  • Lili Zhao

  • Yating Jian

  • Tao Li

  • Meijuan Dang

  • Ziwei Lu

  • Fangcun Li

  • Fan Tang

  • Qingyu Fan

  • Ning Bu

  • Huqing Wang

  • Ru Zhang

  • An Wen

  • Guilian Zhang

  • Hong Fan

  • Lei Zhang

  • April 22, 2026

  • 0 min

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Objective:

To determine the optimal timing of endovascular treatment for acute cerebral infarction with symptomatic intracranial atherosclerotic stenosis (sICAS) in real-world practice, highlighting its significance in improving patient outcomes.

Key Findings:
  • 30-day stroke or death rates were 11.3% in early and 8.3% in delayed groups (p = 0.521).
  • Unfavorable 90-day outcomes were 18.9% in early and 10.7% in delayed groups (p = 0.145).
  • Independent factors influencing intervention timing included higher preoperative NIHSS, albumin-to-globulin ratio, and LDL levels, with statistical significance noted.
  • For posterior circulation lesions, early intervention led to more unfavorable outcomes compared to delayed intervention (29.2% vs. 8.2%, p = 0.033).
Interpretation:

In anterior circulation sICAS with minor stroke, intervention timing may be flexible, while basilar artery lesions are better suited for delayed intervention, which has implications for clinical decision-making.

Limitations:
  • text
Conclusion:

Further prospective studies are needed to validate the findings regarding optimal intervention timing for sICAS, emphasizing the importance of these findings in guiding future research.

Original Source(s)

Timing Considerations for Endovascular Intervention in Patients with Symptomatic Intracranial Atherosclerotic Stenosis: Insights from a Single-Center Real-World Analysis

  • by Yang Yang, Xiaoya Wang, Jialiang Lu, Ye Li, Lili Zhao, Yating Jian, Tao Li, Meijuan Dang, Ziwei Lu, Fangcun Li, Fan Tang, Qingyu Fan, Ning Bu, Huqing Wang, Ru Zhang, An Wen, Guilian Zhang, Hong Fan, Lei Zhang

  • April 22, 2026

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