Case Report: Induction of labor and postpartum management for fetal cardiac rhabdomyoma: a genetic etiology-based analysis of three cases - Summary - MDSpire

Case Report: Induction of labor and postpartum management for fetal cardiac rhabdomyoma: a genetic etiology-based analysis of three cases

  • By

  • Xinying Liu

  • Hongwei Fu

  • Qinggui Ren

  • Hua Shu

  • Guanchen Wu

  • Huiming Xu

  • Xueqin Feng

  • July 9, 2026

  • 0 min

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Objective:

To analyze the genetic factors and perinatal management of fetal cardiac rhabdomyoma (CR) in three cases.

Approach:
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Key Findings:
  • Genetic testing revealed a paternally inherited TSC2 mutation in one case and a de novo TSC1 mutation in another.
  • Differences in recurrence risk and long-term neurological prognosis exist between de novo TSC1 variants and paternally inherited TSC2 mutations.
  • Multidisciplinary care is essential for guiding induction timing, perinatal management, and genetic counseling.
Interpretation:

The study highlights the clinical and genetic heterogeneity of fetal cardiac rhabdomyoma, emphasizing the importance of ultrasound evaluation and genetic testing as part of perinatal management.

Limitations:
  • Limited number of cases in the series.
  • Genetic analysis was declined in one case, limiting comprehensive understanding.
Conclusion:

Timely diagnosis and individualized management are crucial for optimizing maternal and neonatal outcomes in cases of fetal CR.

Original Source(s)

Case Report: Induction of labor and postpartum management for fetal cardiac rhabdomyoma: a genetic etiology-based analysis of three cases

  • by Xinying Liu, Hongwei Fu, Qinggui Ren, Hua Shu, Guanchen Wu, Huiming Xu, Xueqin Feng

  • July 9, 2026

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