Agreement between in vivo and ex vivo photon-counting CT measurements of subchondral trabecular bone features in patients with knee osteoarthritis - Summary - MDSpire

Agreement between in vivo and ex vivo photon-counting CT measurements of subchondral trabecular bone features in patients with knee osteoarthritis

  • By

  • Camilla Toft Nielsen

  • Mikael Boesen

  • Marius Henriksen

  • Janus Uhd Nybing

  • Sophia Wiinberg Bardenfleth

  • Christian Kento Rasmussen

  • Mathias Willadsen Brejnebøl

  • Asbjørn Seenithamby Poulsen

  • Saber Muthanna Aljuboori

  • Kristine Ifigenia Bunyoz

  • Søren Overgaard

  • Anders Troelsen

  • Henning Bliddal

  • Henrik Gudbergsen

  • Felix Müller

  • August 27, 2025

  • 0 min

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Objective:

To investigate the correlation and agreement between in vivo and ex vivo photon-counting CT (PCCT) measurements of subchondral bone features in patients with knee osteoarthritis (OA), emphasizing the clinical significance of these measurements.

Key Findings:
  • In vivo PCCT measurements correlated well with ex vivo measurements for subchondral bone features, with Bland-Altman analysis indicating acceptable agreement, suggesting reliability for clinical assessments.
  • PCCT effectively captured trabecular bone microstructure in vivo, comparable to ex vivo imaging.
Interpretation:

The study demonstrates that in vivo PCCT can reliably assess subchondral bone features in knee OA, providing a non-invasive alternative to ex vivo imaging methods, which could significantly impact future OA research.

Limitations:
  • The study was limited to a specific patient population (obese patients with knee OA), which may introduce biases.
  • The sample size may not be large enough to generalize findings to all OA patients.
Conclusion:

In vivo PCCT is a promising imaging modality for studying bone microstructure in knee OA, potentially aiding in longitudinal studies of disease progression and treatment effects, and warrants further investigation.

Original Source(s)

Agreement between in vivo and ex vivo photon-counting CT measurements of subchondral trabecular bone features in patients with knee osteoarthritis

  • by Camilla Toft Nielsen, Mikael Boesen, Marius Henriksen, Janus Uhd Nybing, Sophia Wiinberg Bardenfleth, Christian Kento Rasmussen, Mathias Willadsen Brejnebøl, Asbjørn Seenithamby Poulsen, Saber Muthanna Aljuboori, Kristine Ifigenia Bunyoz, Søren Overgaard, Anders Troelsen, Henning Bliddal, Henrik Gudbergsen, Felix Müller

  • August 27, 2025

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