Identification of key vaginal microbial signatures and immune remodeling associated with HR-HPV clearance following Kushen Gel treatment: a longitudinal analysis - Summary - MDSpire

Identification of key vaginal microbial signatures and immune remodeling associated with HR-HPV clearance following Kushen Gel treatment: a longitudinal analysis

  • By

  • Ying Wang

  • Shuheng Pan

  • Fengying Zhang

  • Huimin Ma

  • Rihan Wu

  • Jing Zhang

  • Xia Li

  • July 2, 2026

  • 0 min

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Objective:

To elucidate microbial remodeling and immune shifts associated with Kushen Gel-mediated HR-HPV regression.

Approach:
  • Retrospective Analysis: Analyzed 230 vaginal swabs (130 pre-treatment, 100 post-treatment) using 16S rRNA sequencing.
  • Prospective Cohort Study: Validated clinical outcomes in 35 patients with persistent HR-HPV infection, assessing HR-HPV clearance, vaginal pH, Nugent scores, and cytokine levels.
Key Findings:
  • Kushen Gel treatment significantly decreased microbial alpha diversity and shifted beta diversity towards a Lactobacillus-dominant state.
  • HR-HPV clearance rate was 82.9% after three menstrual cycles, with significant reductions in vaginal pH and Nugent scores.
  • Pro-inflammatory cytokines (IL-8, IL-6, TNF-α) decreased significantly, while anti-viral IFN-γ increased.
Interpretation:

Conclusion:

Original Source(s)

Identification of key vaginal microbial signatures and immune remodeling associated with HR-HPV clearance following Kushen Gel treatment: a longitudinal analysis

  • by Ying Wang, Shuheng Pan, Fengying Zhang, Huimin Ma, Rihan Wu, Jing Zhang, Xia Li

  • July 2, 2026

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