Intralesional Vitamin D versus Triamcinolone Acetonide for the Treatment of Keloids: A Systematic Review and Meta-analysis of Randomized Controlled Trials - Summary - MDSpire

Intralesional Vitamin D versus Triamcinolone Acetonide for the Treatment of Keloids: A Systematic Review and Meta-analysis of Randomized Controlled Trials

  • By

  • Jiang, Dan

  • Liu, Yalan

  • Li, Sheng

  • Wang, Ximao

  • You, Shunjie

  • May 22, 2026

  • 0 min

Share

Objective:

To evaluate the comparative efficacy and safety of intralesional vitamin D versus triamcinolone acetonide (TAC) in the management of keloids.

Key Findings:
  • TAC demonstrated superior efficacy in improving scar severity (MD = -9.72; 95% CI -17.41 to -2.02; p = 0.013).
  • TAC was more effective in lesion flattening (RR = 0.68; 95% CI 0.48 to 0.96; p = 0.028).
  • Vitamin D was associated with significantly lower risks of pigmentation changes (RR = 0.23; 95% CI 0.07 to 0.78; p = 0.018) and skin atrophy (RR = 0.51; 95% CI 0.32 to 0.82; p = 0.006).
  • No significant differences were found in pain, erythema, telangiectasia, or blister formation between the two treatments.
Interpretation:

Limitations:
  • The evidence base is limited, necessitating cautious interpretation of findings.
Conclusion:

Original Source(s)

Intralesional Vitamin D versus Triamcinolone Acetonide for the Treatment of Keloids: A Systematic Review and Meta-analysis of Randomized Controlled Trials

  • by Jiang, Dan , Liu, Yalan , Li, Sheng , Wang, Ximao , You, Shunjie

  • May 22, 2026

Related Content

A clinical investigation using reflectance confocal microscopy to evaluate the add-on efficacy of the Shumin treatment instrument combined with doxycycline for rosacea

Meta-inflammation in Hidradenitis suppurativa: from pathogenic evidence to therapeutic approaches

Intercellular mitochondrial transfer in melanoma progression and therapeutic resistance: mechanisms and targeting potential