Objective oculomotor, vestibular, reaction time, and cognitive signatures of vestibular migraine - Summary - MDSpire

Objective oculomotor, vestibular, reaction time, and cognitive signatures of vestibular migraine

  • By

  • Claire E. J. Ceriani

  • Alexandr Braverman

  • Alexander Kiderman

  • May 20, 2026

  • 0 min

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Objective:

To evaluate oculomotor, vestibular, reaction time, and cognitive (OVRT-C) function in patients with vestibular migraine (VM) using objective eye-tracking metrics and to identify dysfunction patterns relative to healthy controls.

Key Findings:
  • 54.3% of VM patients showed abnormal horizontal saccades (p < 0.0001).
  • 62.9% exhibited abnormal vertical smooth pursuit (p < 0.0001).
  • 65.7% demonstrated impaired gaze stability (p < 0.0001).
  • A multiple logistic regression model identified six OVRT-C metrics as significant indicators of VM with AUC = 0.996.
Interpretation:

Objective OVRT-C testing reveals quantifiable abnormalities in oculomotor, vestibular, and cognitive functions in VM patients, supporting the use of eye-tracking assessments for characterizing the disorder and improving clinical diagnosis.

Limitations:
  • Study sample size was limited to 52 participants.
  • Results may not be generalizable to all VM patients due to the specific recruitment setting.
  • Potential biases in participant recruitment may affect the findings.
Conclusion:

The findings support the feasibility of eye-tracking–based multimodal assessments as complementary tools for characterizing vestibular migraine, warranting further validation in larger and more diverse cohorts.

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