Platelet-Rich Plasma Reduces Pain After Tonsillectomy - Summary - MDSpire

Platelet-Rich Plasma Reduces Pain After Tonsillectomy

Randomized trial shows reduced postoperative pain and faster mucosal healing without increased bleeding risk

  • By

  • Mouj Hijazi

  • March 27, 2026

  • 3 min

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Objective:

To evaluate the effects of topical autologous platelet-rich plasma (PRP) on postoperative pain and wound healing in patients undergoing tonsillectomy.

Approach:
    Key Findings:
    • Patients treated with PRP experienced significantly lower pain scores (average reduction of 0.8 points on VAS) compared to control.
    • Pain reductions were most significant during the first 8 days postoperation.
    • Wound healing scores were significantly improved at postoperative days 7, 10, and 14.
    • Complete mucosal healing by day 14 occurred in 78% of PRP-treated patients versus 59% in the control group.
    • Postoperative bleeding rates were low and similar between groups.
    Interpretation:

    PRP may enhance healing through growth factors that promote epithelialization and tissue repair, suggesting its utility in improving early recovery after tonsillectomy.

    Limitations:
    • Single-center design limits generalizability.
    • Lack of age-stratified analyses.
    • Limited power to detect differences in rare outcomes such as bleeding.
    Conclusion:

    Intraoperative PRP may be a beneficial adjunct for improving postoperative recovery in tonsillectomy, warranting further multicenter studies.

    Sources:

Original Source(s)

Platelet-Rich Plasma Reduces Pain After Tonsillectomy

  • by Mouj Hijazi

  • March 27, 2026

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