The effects of high-intensity interval training on glucose metabolism, inflammatory responses, and functional recovery in patients with diabetic peripheral neuropathy - Summary - MDSpire

The effects of high-intensity interval training on glucose metabolism, inflammatory responses, and functional recovery in patients with diabetic peripheral neuropathy

  • By

  • Genchun Guo

  • Zhenhua Zhu

  • Xin Shao

  • Feixiang Ma

  • Chunyan Xing

  • Yunlan Huang

  • Wanlang Li

  • June 18, 2026

  • 0 min

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Objective:

To investigate the effects of high-intensity interval training (HIIT) on glucose metabolism, inflammatory responses, and neurological recovery in patients with diabetic peripheral neuropathy (DPN), and to compare these effects with moderate-intensity continuous training (MICT).

Approach:
    Key Findings:
    • Both HIIT and MICT improved HbA1c, FPG, and HOMA-IR levels compared to the control group.
    • HIIT and MICT reduced inflammatory factors (TNF-α, IL-6, CRP) and promoted recovery of nerve conduction velocities and clinical function.
    • HIIT showed more significant improvements in HbA1c, FPG, TNF-α, IL-6, and TCSS scores compared to MICT.
    Interpretation:

    HIIT and MICT can effectively improve glucose metabolism, reduce chronic inflammation, and enhance nerve function recovery in DPN patients, with HIIT providing superior benefits.

    Conclusion:

    HIIT is more effective than MICT in improving health outcomes for patients with DPN.

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