Association between the albumin-to-lymphocyte ratio and short-term mortality in critically Ill pediatric patients: a retrospective cohort study and machine learning analysis - Summary - MDSpire
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Association between the albumin-to-lymphocyte ratio and short-term mortality in critically Ill pediatric patients: a retrospective cohort study and machine learning analysis
To investigate the association between early albumin-to-lymphocyte ratio (ALR) and short-term all-cause mortality in pediatric intensive care unit (PICU) patients and evaluate its predictive utility.
Key Findings:
The overall 28-day mortality rate was 4.53% among 7,591 critically ill children.
The intermediate ALR tertile showed the lowest observed 28-day mortality and highest survival probability.
In the fully adjusted Cox model, both intermediate and highest ALR tertiles were associated with lower mortality risk compared to the lowest tertile.
Restricted cubic spline analysis indicated a non-linear association between ALR and mortality.
The XGBoost machine learning model achieved the best performance with an AUC of 0.835.
Interpretation:
Limitations:
The study is retrospective and conducted at a single center, which may limit generalizability.
Potential confounding factors may not have been fully accounted for despite adjustments.
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