The Screening Tomosynthesis Trial with Advanced Reader Methods (STREAM): design and rationale of a population-based breast cancer screening trial - Summary - MDSpire

The Screening Tomosynthesis Trial with Advanced Reader Methods (STREAM): design and rationale of a population-based breast cancer screening trial

  • By

  • Lindy Kregting

  • Daan van den Oever

  • Lian Pennings

  • Ruud Pijnappel

  • Nicolien van Ravesteyn

  • Ellen Verschuur

  • Marja van Oirsouw

  • Loes Dunning

  • Hans ‘t Mannetje

  • Ruben van Engen

  • Adriana Bluekens

  • Maartje Smid-Geirnaerdt

  • Cary van Landsveld-Verhoeven

  • Nehmat Houssami

  • Ioannis Sechopoulos

  • Mireille Broeders

  • January 9, 2025

  • 0 min

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Objective:

To determine the outcomes and cost-effectiveness of nationwide digital breast tomosynthesis (DBT) breast cancer screening in the Netherlands using optimal image acquisition and interpretation strategies, including specific methods to be evaluated.

Key Findings:
  • DBT has shown improved cancer detection rates in studies but no significant effect on interval cancer rates, raising questions about its necessity in a high-performing screening program.
  • The Dutch programme's current detection rate is already high, prompting a need to evaluate the added value of DBT.
  • Optimizing DBT interpretation is crucial for feasibility in terms of economic and human resources, which may influence implementation.
Interpretation:

The STREAM trial aims to assess whether DBT can enhance breast cancer screening outcomes in the Netherlands while maintaining cost-effectiveness and stakeholder acceptability, potentially shaping future screening practices.

Limitations:
  • Exclusion of wheelchair-bound individuals may limit generalizability, as this group may have different screening needs.
  • Potential increase in recall rates with DBT is uncertain, necessitating further investigation.
Conclusion:

The STREAM trial will provide valuable insights into the effectiveness and acceptability of DBT in breast cancer screening, potentially influencing future screening practices in the Netherlands.

Original Source(s)

The Screening Tomosynthesis Trial with Advanced Reader Methods (STREAM): design and rationale of a population-based breast cancer screening trial

  • by Lindy Kregting, Daan van den Oever, Lian Pennings, Ruud Pijnappel, Nicolien van Ravesteyn, Ellen Verschuur, Marja van Oirsouw, Loes Dunning, Hans ‘t Mannetje, Ruben van Engen, Adriana Bluekens, Maartje Smid-Geirnaerdt, Cary van Landsveld-Verhoeven, Nehmat Houssami, Ioannis Sechopoulos, Mireille Broeders

  • January 9, 2025

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