Objective:

To investigate the impact of vaccination status on specific biomarker levels related to glucose metabolism, renal function, and inflammation in COVID-19 survivors, enhancing clinical follow-up.

Key Findings:

• Vaccination status significantly influenced biomarker levels related to glucose metabolism, renal function, and systemic inflammation, highlighting the importance of vaccination in public health.
• Individuals receiving three or more vaccine doses exhibited better metabolic and inflammatory profiles compared to unvaccinated individuals, suggesting a protective effect.
• Short-term increases in inflammatory markers post-vaccination normalized quickly without long-term effects, indicating the transient nature of these changes.

Interpretation:

The study suggests that vaccination may mitigate long-term complications associated with COVID-19, particularly in metabolic and inflammatory parameters, emphasizing the need for vaccination in at-risk populations.

Limitations:

• The study is mono-centered, which may limit generalizability; findings may not be applicable to diverse populations.
• Exclusion of smokers may affect the applicability of findings to broader populations, as smoking can influence inflammation and health outcomes.

Conclusion:

Vaccination against COVID-19 appears to play a crucial role in improving long-term health outcomes in survivors, warranting further research into specific biomarkers and their implications for public health strategies.