Changes in Bone Microarchitecture and Inflammatory Cytokines After Cure of Chronic Hepatitis C Infection With Direct-Acting Antiviral Therapy - Summary - MDSpire

Changes in Bone Microarchitecture and Inflammatory Cytokines After Cure of Chronic Hepatitis C Infection With Direct-Acting Antiviral Therapy

  • By

  • Vincent Lo Re

  • Dean M Carbonari

  • Craig W Newcomb

  • Jessie Torgersen

  • Erica J Weinstein

  • Shanae M Smith

  • Katherine L Brecker

  • X Sherry Liu

  • Jay R Kostman

  • Stacey Trooskin

  • Rebecca A Hubbard

  • Joshua F Baker

  • Babette S Zemel

  • Mary B Leonard

  • September 15, 2025

  • 0 min

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Objective:

To evaluate changes in inflammatory cytokines and bone measurements following cure of chronic hepatitis C with direct-acting antivirals (DAAs), specifically assessing post-treatment outcomes.

Key Findings:
  • No significant differences in bone microarchitecture changes between cured HCV participants and controls, indicating no improvement.
  • Cured HCV participants showed significant decreases in IL-18 and TNF-α levels compared to controls.
  • No significant change in IL-6 levels between groups.
Interpretation:

Curing HCV with DAAs does not appear to improve bone microarchitecture but is associated with reduced levels of certain inflammatory cytokines, which may have broader health implications.

Limitations:
  • Small sample size may limit generalizability.
  • Short follow-up period of 18 months may not capture long-term effects.
  • Potential biases in participant selection could affect results.
Conclusion:

While DAA therapy reduces inflammatory cytokines, it does not significantly improve bone microarchitecture in individuals cured of chronic HCV.

Original Source(s)

Changes in Bone Microarchitecture and Inflammatory Cytokines After Cure of Chronic Hepatitis C Infection With Direct-Acting Antiviral Therapy

  • by Vincent Lo Re, Dean M Carbonari, Craig W Newcomb, Jessie Torgersen, Erica J Weinstein, Shanae M Smith, Katherine L Brecker, X Sherry Liu, Jay R Kostman, Stacey Trooskin, Rebecca A Hubbard, Joshua F Baker, Babette S Zemel, Mary B Leonard

  • September 15, 2025

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