Diet Quality and Dementia Risk in Older Adults With Alzheimer Pathology

To analyze how dietary patterns may modify dementia risk across strata of biological risk in older adults with Alzheimer’s disease pathology.

Dementia Diagnosis: Dementia incidence was assessed through structured interviews, clinical examinations, and cognitive testing, with diagnoses made according to established criteria, including the Diagnostic and Statistical Manual of Mental Disorders (Fourth Edition) and National Institute of Neurological and Communicative Disorders and Stroke–Alzheimer’s Disease and Related Disorders Association criteria.

Blood-based biomarkers such as p-tau217, NFL, and GFAP are correlated with AD pathology and may predict dementia risk.
Adherence to healthy dietary patterns like the Mediterranean diet is associated with better brain health and lower dementia risk.
Dietary patterns with high inflammatory potential are linked to worse brain health markers and increased dementia risk.

The study may not account for all potential confounding factors influencing the association between diet and dementia risk.
Longitudinal data may have limitations in capturing changes in dietary habits over time.