Distinct Gut Microbiota Signatures Associated With Progression of Atherosclerosis in People Living With Human Immunodeficiency Virus - Summary - MDSpire
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Distinct Gut Microbiota Signatures Associated With Progression of Atherosclerosis in People Living With Human Immunodeficiency Virus
To examine the relationship between gut microbiota composition dynamics and the progression of subclinical atherosclerosis specifically in virologically suppressed individuals with HIV.
Key Findings:
43% of participants showed atherosclerosis progression, with 26.7% developing new carotid plaque. Distinct microbial profiles were statistically significant between groups with and without cIMT progression.
Agathobacter and Ruminococcus 2 were associated with cIMT progression, while Prevotella 7 was linked to non-progression.
Interpretation:
The study suggests that specific gut microbiota profiles may influence the progression of atherosclerosis in people with HIV, highlighting the potential role of the microbiome in cardiovascular health.
Limitations:
The study excluded participants on protease inhibitors, limiting generalizability. The sample size decreased over time, potentially affecting the robustness of findings. The observational nature of the study does not establish causation, which should be considered when interpreting results.
Conclusion:
Distinct gut microbiota signatures may be linked to atherosclerosis progression in HIV-infected individuals, warranting further investigation into specific microbiome-targeted interventions.
by Mar Masiá, José A García, Javier García-Abellán, Sergio Padilla, Marta Fernández-González, Vanesa Agulló, Maria José Gosalbes, Sonia Ruíz-Pérez, Paula Mascarell, Angela Botella, Félix Gutiérrez
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