Objective:

To assess the diagnostic yield of frame-based stereotactic biopsies for intracranial lesions, with a focus on the critical role of tissue molecular genetics in advancing neuro-oncology.

Key Findings:

• 145 patients included, average age 58.3 years, with a majority having deep-seated lesions. The findings underscore the need for effective diagnostic strategies in neuro-oncology.
• Final diagnoses included glioma (63%), lymphoma (16%), inflammatory disease (10%), and confirmed metastases (3%). These results highlight the diverse pathology encountered in this patient population.
• 8% of patients had multifocal lesions, with glioma being the most suspected diagnosis preoperatively, indicating the complexity of diagnosis in such cases.

Interpretation:

The study indicates that frame-based stereotactic biopsies provide a sufficient diagnostic yield for molecular profiling in neuro-oncology, thereby supporting the development of personalized therapy approaches based on molecular characteristics.

Limitations:

• Retrospective design may introduce bias, potentially affecting the reliability of the findings.
• Limited generalizability due to single-center study, which may not reflect broader clinical practices.
• Potential for inconclusive results despite adequate tissue sampling, which could impact treatment decisions.

Conclusion:

Frame-based stereotactic biopsies are effective in obtaining sufficient tissue for molecular diagnostics, which is crucial for advancing personalized treatment strategies in neuro-oncology.